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Antidepressants Antidepressants Make a Way for Weight Gain

Reviewed by
Dr. Pradip Chauhan


An antidepressant is a psychiatric medication used to alleviate mood disorder such as major depression and dysthymia

Types of Antidepressants

  • Selective serotonin reuptake inhibitors (SSRIs)
  • Serotonin-norepinephrine reuptake inhibitors (SNRIs)
  • Noradrenergic and specific serotonergic antidepressants (NaSSAs)
  • Norepinephrine (noradrenaline) reuptake inhibitors (NRIs)
  • Norepinephrine-dopamine reuptake inhibitors (NDRIs)
  • Selective serotonin reuptake enhancers (SSREs)
  • Melatonergic agonists
  • Tricyclic antidepressants (TCAs)
  • Tertiary Amine Tricyclic Antidepressants
  • Secondary Amine Tricyclic Antidepressants
  • Augmenter drugs

Side effects

Antidepressant comes with lots of side effects like Suicide, Sexual bed performance,Thymoanesthesia, impaired REM Sleep and Weight gain

Weight gain is one of the comonest side effect it

Many antidepressants are associated with weight gain usually in the range of 525 kg (1155 lb) but rarely upwards of 50 kg (110 lb).

The specific cause is unknown, but antidepressants are associated with increased cravings, an inability to feel full despite consuming enough calories, low energy levels and increased daytime sleepiness, which can lead to overeating and a lack of desire to exercise, and dry mouth, which can lead to ingestion of calorie-laden beverages.

The antihistaminic properties of certain NaSSA and TCA class antidepressants have been shown to contribute to the common side effects of increased appetite and weight gain associated with these classes of medication.


Eating low fat, low protein carbohydrate snacks and carbohydrate-rich dinners allows the brain to make serotonin which then controls appetite and balances mood. Carbohydrates thus eaten, as part of a balanced diet, by virtue of their effect on brain serotonin levels, can support weight loss in the setting of antidepressant weight gain.


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